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Ganoderma Lucidum - Red Reishi Mushroom   Studies on Cancer Biology
  Clinical Studies on Ganoderma Lucidum
Studies on Ganoderma Lucidum and Specific Cancers
Studies on Ganoderma Lucidum and Cancer Biology

Oligosaccharide and Peptidoglycan of Ganoderm lucidum Activate the Immune Reponse in Human Mononuclear Cells
Tsai CC et al
Journal of Agricultural Food Chemistry, 2012
Fragments of Ganoderma polysaccharides are able to induce immune responses in human immune cell. A fragment containing glucuronic acid and glucose residues is most potent in this immune cell assay.

Antitumor Properties of Ganoderma lucidum Polysaccharidis and Terpenoids
Marcela Camargo et al
Annual Review of Biomedical Sciences 2012
Reviews the direct effect of the polysaccharides and terpeoids of Ganoderma have on tumor cells including apoptosis (cell death) and interference in the cell cycle. Their data indicates that Ganoderma can be used as a complementary tool for treatment of cancer patients.

Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to
activate lymphocytes

Sun LX, et al.
Basic and Clinical Pharmacology and Toxicology, 2011
The immune system in patients with cancer often fails to control tumor growth because of deficient immunogenicity of tumor cells Ganoderma polysaccharides are shown to
activate lymphocyte proliferation in cancer cells (melanoma).

Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom).
Gao P, et al
Fitoterapia. 2012

Enhanced MHC class I and costimulatory molecules on B16F10 cells by Ganoderma lucidum polysaccharides.
Sun LX, et al
J Drug Target. 2012

Ergosterol peroxide isolated from Ganoderma lucidum abolishes microRNA miR-378-mediated tumor cells on chemoresistance.
Wu QP, et al
PLoS One. 2012

Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin.
Yao X,et al
Planta Med. 2012
These 2 papers show that extracts of Ganoderma enhance the killing of cancer cells by normal immune killer cells and reduce the amount of chemotherapy drugs needed.

Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom).
Gao P, et al
Fitoterapia. 2012

Ganoderma lucidum total triterpenes prevent radiation-induced DNA damage
and apoptosis in splenic lymphocytes in vitro.

Simina TP, et al.
Mutation Research, 2011
Study showing that Ganoderma triterpenes have a remarkable ability to protect normal cells from radiation-induced damage. Radiation can cause cancer, so relevant to cancer prevention.

Antitumor and anti-inflammatory activities of polysaccharides isolated from
Ganoderma lucidum (2011)

Joseph S, et al.
Acta Pharmacologica Sinica, 2011
Ganoderma polysaccharides inhibit growth of solid tumors

Ganoderma lucidum,the most eclectic mushroom: useful in oncology or against virus, inflammation or metabolic diseases.
B. Donatini
Phytotherapie, 2011
Review of the apoptotic effects of Ganoderma, in cancer and other diseases

Apoptic and Immune Restoration Effects of Ganoderic Acids Define a New
Prospective for Complementary Treatment of Cancer (Radwan et al) - J. Clinical Cell Immunology, 2011

Faisal F.Y. Radwan et al
Journal of Clinical and Cellular Immunology, 2011
Readable review of the stimulatory effects of Ganoderma ganoderic acids on apoptosis and the immune system. .

Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells
Q.-X. Yue et al
Phytomedicine 2010
Five different ganoderic acids inhibit proliferation of human HeLa cancer cells
Ganoderic acids might exert their cytotoxicity by altering proteins involved in cell proliferation and/or cell death, carcinogenosis, oxidative stress, calcium signaling and ER stress.

GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays anti- tumour activity by increasing both humoral and cellular immune response
Jingsong Zhang et al
Life Sciences 2010
First report that a Ganoderma proteoglycan (a protein with attached carbohydrate) called GLIS can have anti-cancer effects. GLDIS given to mice with sarcomas inhibited growth of the sarcoma by 60%. The authors link this to proliferation of B lymphocytes in the immune system of the mice.

The in vitro and in vivo experimental evidences disclose the chemopreventive
effects of Ganoderma lucidum on cancer invasion and metastasis.

Weng CJ, et al.
Clinical and Experiemental Metastasis, 2010
Review of how Ganoderma modifies activation of intracellular signaling proteins, resulting in suppression of genes thought to be involved in metastasis. Discussion of how Ganoderma polysaccharides and triterponoids protect against cancer metastasis and invasive cellular mechanisms.

Free-radical scavenging and mitochondrial antioxidant activities of Reishi-Ganoderma lucidum (Curt: Fr) P. Karst and Arogyapacha-Trichopus zeylanicus Gaertn extracts.
Cherian E, et al
J Basic Clin Physiol Pharmacol. 2009

Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum.
Dudhgaonkar S, et al
Int Immunopharmacol. 2009

Ganoderma lucidum: a potent pharmacological macrofungus.
Sanodiya BS, et al
Curr Pharm Biotechnol. 2009

Antiinflammatory triterpenoids and steroids from Ganoderma lucidum and G. tsugae.
Ko HH, et al
Phytochemistry. 2008

Antitumor activity of extracts of Ganoderma lucidum and their protective effects on damaged HL-7702 cells induced by radiotherapy and chemotherapy.
Wang DJ, et al.
Journal of Chinese Materia Medica 2006
Ganoderma is useful to support the immune system with people undergoing chemotherapy and radiotherapy. Ganoderma had protective effects on damaged normal cells induced by radiotherapy and chemotherapy.

Polysaccharide Purified from Ganoderma lucidum Induces Gene Expression
Changes in Human Dendritic Cells and Promotes T Helper 1 Immune Response in BALB/c Mice

Yu-Li Lin et al
Molecular Pharmacology 2006
This study shows that one of the active molecules in Ganoderma is a branched glucan polysaccharide. The polysaccharide can stimulate the immune system, in part by inducing the expression of interleukin molecules in the bloodstream. No analysis of cancer effects, but indirectly relevant to cancer.

Review of the evidence that Ganoderma polysaccharides and triterpenes have anti-cancer and other health providing effects.
R. Russell M Paterson
Phytochemistry, 2006
Ganoderma – A Therapeutic fungal biofactory

Polysaccharide purified from Ganoderma lucidum induces gene expression changes in human dendritic cells and promotes T helper 1 immune response in BALB/c mice.
Lin YL, et al
Mol Pharmacol. 2006

Effect of Ganoderma lucidum on human DNA is dose dependent and mediated by hydrogen peroxide.
Wachtel-Galor S, et al
Redox Rep. 2005

Effects of Ganoderma lucidum polysaccharides on proliferation and cytotoxicity of cytokine-induced killer cells
Zhu XL et al
Acta Pharmacologica Sinica 2005
Ganoderma polysaccharides act on cytokine-induced killer cells (CIK cells) in the blood to stimulate the immune system..

Anticancer effects of Ganoderma lucidum: a review of scientific evidence.
Review of the potential of Ganoderma spores to treat cancer, emphasizing the potential as a real therapy and not just in scientific studies.and essays.
Yuen JW et al.
Nutrition and Cancer, 2005

Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its
possible mechanisms

Lin ZB, et al.
Acta Pharmacologica Sinica, 2004
Abstract showing Ganoderma polysaccharides anti-tumor effects by inhibiting
angiogenesis (development of a blood supply) to the tumor.

Cultivation, Utlization, and Medicinal Effects of Ganoderma Lucidum in Malaysia
Teow Sun-Soo
MARA Institute of Technology 2004.
Summary of various human trials – on leukaemia, nasopharyngeal carcinoma, diabetes, hypertension, hepatitis.

Role of Ganoderma Supplementation in Cancer Management
Raymond Y. Chang
Cornell Medical College 1999
A review from 1999 outlining Ganoderma’s use for cancer patients as a supplement to enhance the effects chemotherapy/radiotherapy and reducing side-effects. The author suggests using this supplement to enhance survival and reduce likelihood of metastasis.
(interesting, as most of the scientific research on cancer and Ganoderma is from 2003 to present day)

This website presents an up-to-date selection of the most important Ganoderma research discoveries of recent years, with a focus on cancer research.